University of Utah
Thursday, Sept 13, 2012
Refreshments: 3:30 pm in 219 JFB
Lecture 4:00pm (102 JFB)
Title: Biophysics of Microtubule-Based Molecular Motors
Much of the motion observed in biology originates at a molecular level and can be traced to the functioning of just a few protein types often collectively referred to as molecular motors. The talk will specifically focus on processive microtubule-based motors responsible for most long distance transport inside eukaryotic cells. Such motors can be thought of as standalone mechanochemical machines but must also be understood in their native biological context. At present, neither function has a comprehensive quantitative description. The talk will discuss the challenges in the field, highlight our recent single molecule results contrasting single molecule function of kinesin and dynein motors and discuss their implications for microtubule-based transport in cells. I will also present our early efforts to study motor transport on complex filament networks. In addition, future directions and questions of interest will be briefly discussed.