logo
Michael Vershinin Lab
kinesin
Motor regulation
(Image courtesy of David Meikle)

Our lab works at the interface of biophysics, biochemistry, nanoscale engineering, and math biology. We develop and employ new ways to reconstruct and carefully measure the world of biology under controlled conditions. We use a variety of biophysical and biochemical tools to examine biological phenomena at the single molecule level and to then work our way up.

kinesin
Motility driven by heterogenous motor ensembles

The lab is currently focused on the properties of the microtubule cytoskeleton and the associated cargo transport. We are interested in how individual molecular motors which move cargos can be regulated by various biochemical factors and biophysical parameters. But more than that, we want to know how one takes this local machinery and builds an efficient logistics system out of it.

3D routing
3D cytoskeleton & associated complex logistics

How are cargos routed? How is the cargo delivery timed? How do cargos navigate the complex cytoskeleton to build optimal spatial cargo distribution? What is the role of the mechanical response of the microtubules to cargos pushing their way through? And incidentally, what is the logistics in cells optimized for?
In short, we aim to rationalize and quantify emergent complexity of the cytoskeleton and associated motility. Our goal is to bring together the local and the global picture of the microtubule-associated world.

Positions Open

Postdoctoral, Graduate, and Undergraduate

As a group operating at the interface of biology, physics, math, engineering, and chemistry we have a lot of interests and a few cool toys to play with (from the microscopy equipment we are building to the software we are developing). We are expending, so inquiries at all levels and from a wide range of backgrounds are welcome. Contact